Treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of seizures. The rate of intravenous infusion for the second dose ranges from 15 minutes (for patients extremely unstable) to 2 hours based on patient condition.įor instructions on reconstitution of the medicinal product before administration, see section 6.6. Initial dose of Cyanokit is administered as an intravenous infusion over 15 minutes. Paediatric population: In infants to adolescents (0 to 18 years old), the maximum total recommended dose is 140 mg/kg not exceeding 10 g.Īlthough the safety and efficacy of hydroxocobalamin have not been studied in renal and hepatic impairments, Cyanokit is administered as emergency therapy in an acute, life-threatening situation only and no dose adjustment is required in these patients.

Paediatric population: In infants to adolescents (0 to 18 years old), the subsequent dose of Cyanokit is 70 mg/kg body weight not exceeding 5 g.Īdults: The maximum total recommended dose is 10 g. Depending upon the severity of the poisoning and the clinical response (see section 4.4), a second dose may be administered.Īdults: The subsequent dose of Cyanokit is 5 g (200 mL, complete volume of reconstituted solution).

Hydroxocobalamin cyanide mechanism